Journal of Disability and Oral Health

cover art

Cover Date:
December 2006
Print ISSN:
1470-8558
Electronic ISSN:
1754-2758
Vol:
7
Issue:
3

Salivary methotrexate following IV therapy for osteosarcoma: a pilot study

Aim: Exposure to antineoplastic drugs poses risk to health providers who may be treating children u n d e r g o i n g cancer or immune therapy. Objective: This study compares methotrexate (MTX) concentrations in saliva and plasma against a concentration standard for lymphocyte mutagenicity (0.100 µmol/L). Design: Five osteosarcoma patients expectorated 5mL of unstimulated saliva into a sterile collection tube at 24, 48 and 72 hours post-MTX administration, paralleling blood sampling, and yielding 33 samples. Saliva was analysed using fluorescence polarization immunoassay (FPIA) to determine MTX concentrations; creatinine and blood urea nitrogen (BUN) also were measured using standard techniques. Results: Mean saliva MTX at 24 hours (0.138µmol/L) exceeded in vitro mutagenic standard, but did not at 48h and 72h post infusion. Key Words: Methotrexate, anti-neoplastic drugs, dental personnel, saliva, plasma

Article Price
£15.00
Institution Article Price
£15.00
Page Start
153
Page End
155
Authors
F Michael Beck, Reginald Eswuedo, Dennis J McTigue, Paul S Casamassimo, Sarat Thikkurissy

Articles from this issue

  • Title
  • Pg. Start
  • Pg. End

  1. Editorial
  2. 142
  3. 142

  1. Defining the population requiring special care dentistry using the International Classification of Functioning, Disability and Health – a personal view
  2. 143
  3. 152

  1. Salivary methotrexate following IV therapy for osteosarcoma: a pilot study
  2. 153
  3. 155

  1. Hypnosis – alternative, or complimentary to conscious sedation in dentistry? A review
  2. 156
  3. 162

  1. Guidelines for the delivery of a Domiciliary Oral Health Care Service.
  2. 166
  3. 172

  1. Oral disease experience of adults with severe disability, prior to receiving dental treatment under general anaesthesia
  2. 173
  3. 175

  1. Overview of a hospital based dental programme for persons with special needs
  2. 176
  3. 184

  1. Flow rate, pH and buffer capacity in saliva of adolescents with cerebral palsy
  2. 185
  3. 188

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