Community Dental Health

cover art

Cover Date:
September 2008
Print ISSN:
0265 539X
Vol:
25
Issue:
3

Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration

Objective The aim of this work was to analyze pH and sugar concentration in seven antiretroviral and three antibacterial medications frequently prescribed to HIV infected paediatric patients. Method Sugars (sucrose, glucose, lactose and fructose) and pH were measured from every one of ten medications with different serial numbers in two samples. The pH was determined by a previously calibrated digital pHmeter (Beckman™). Analysis of free sugars was performed using thin-layer chromatography (TLC). The pH results and the amount of sugar originated from the two samples in each lot were added. The arithmetic mean of these results were computed. Results Two antiretrovirals (Zidovudin and Abacavir Sulphate) had pH below critical level (3.55 and 3.93, respectively). All three antibacterials analyzed had pH above 5.5, and one of them (Azithromycin) had the highest pH level of the ten medications examined (9.28). Sugar was present in seven out of 10 of the medications analyzed. The antibacterials contained the highest concentration of sucrose, ranging from 40% to 54%. Glucose was found in one of the ten, sucrose was present in seven of them and none showed lactose. Fructose was not observed with the technique used. Conclusions A number of medications frequently used by HIV-infected children may cause a significant risk of both caries and dental erosion.

Key words: Child, HIV, medicines, oral health, sugars.

Article Price
£15.00
Institution Article Price
£
Page Start
170
Page End
172
Authors
L. Pomarico, G. Czauski, M.B. Portela, I.P.R. de Souza, L. Kneipp, R.M. de Araújo Soares, G.F.B de Araújo Castro

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  1. Comparison of two methods in deriving a short version of oral health-related quality of life measure.
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  1. Oral health and its impact on the life quality of homeless people in Hong Kong
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  1. The presenting complaints of low income adults for emergency dental care: An analysis of 35,000 episodes in Victoria, Australia.
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  1. International variation in the incidence of oral and pharyngeal cancer
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  1. Caries prevalence in 2-year-old children in the city of Zurich
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  1. Association between breastfeeding duration and non-nutritive sucking habits
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  1. I want braces: factors motivating patients and their parents to seek orthodontic treatment.
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  1. Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration
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  1. Prevalence of breath malodour in 7-11 year old children living in Middle Anatolia, Turkey.
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  1. Enamel fluorosis in 12- and 15-year-old school children in Costa Rica. Results of a National Survey, 1999
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  1. Restorative treatment threshold reported by Iranian dentists
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  1. Short Communication - Fissure sealants on permanent first molars – consequences of a one-year delay
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